From the South:
I-90/94 toward Chicago
RIGHT (east) onto I-290 (Eisenhower Expy)
---Road name changes to Congress Pkwy
LEFT (north) onto S. Dearborn St
LEFT (west) onto W. Adams St
Look to the right for the large red 'W'

From the North:
I-90/94 toward Chicago
RIGHT onto Exit 51B
LEFT (east) onto W. Jackson Blvd
LEFT (north) onto S. LaSalle St
LEFT (west) onto W. Adams St
Look to the right for the large red 'W'

From the West:
EAST on I-290 (Eisenhower Expy)
---Road name changes to Congress Pkwy
LEFT (north) onto S. Dearborn St
LEFT (west) onto W. Adams St
Look to the right for the large red 'W'

Via El:
1 block NE of Quincy Brown/Orange/Purple line
4 blocks SW of Monroe/Dearborn Blue Line
5 blocks SW of Monroe/State Red Line
[CTA Trip Planner]

Via Train:
Metra & Amtrak train station are located a few blocks West.

From Chicago Midway Airport:
NORTH on Cicero Avenue
NORTHEAST on I-55
NORTH onto I-94 (downtown)
Take the Monroe Street exit
RIGHT (east) onto Monroe Street and drive nine blocks until you come to LaSalle Street
RIGHT (south) onto LaSalle Street and drive one block to Adams Street
RIGHT (west) onto Adams Street
 
From O'Hare International Airport:
SOUTHEAST I-90/94 (downtown)
Take the Monroe Street exit
LEFT (east) onto Monroe Street and drive nine blocks until you come to LaSalle Street
RIGHT (south) onto LaSalle Street and drive one block to Adams Street
RIGHT (west) onto Adams Street